Ontology highlight
ABSTRACT:
SUBMITTER: Laouari D
PROVIDER: S-EPMC3029905 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Laouari Denise D Burtin Martine M Phelep Aurélie A Martino Carla C Pillebout Evangeline E Montagutelli Xavier X Friedlander Gérard G Terzi Fabiola F
Journal of the American Society of Nephrology : JASN 20101223 2
The mechanisms of progression of chronic kidney disease (CKD) are poorly understood. Epidemiologic studies suggest a strong genetic component, but the genes that contribute to the onset and progression of CKD are largely unknown. Here, we applied an experimental model of CKD (75% excision of total renal mass) to six different strains of mice and found that only the FVB/N strain developed renal lesions. We performed a genome-scan analysis in mice generated by back-crossing resistant and sensitive ...[more]