Ontology highlight
ABSTRACT:
SUBMITTER: Keck GE
PROVIDER: S-EPMC3030632 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20101222 4
Bryostatin 1 is a marine natural product that is a very promising lead compound because of the potent biological activity it displays against a variety of human disease states. We describe herein the first total synthesis of this agent. The synthetic route adopted is a highly convergent one in which the preformed, heavily functionalized pyran rings A and C are united by "pyran annulation", the TMSOTf-promoted reaction between a hydroxyallylsilane appended to the A-ring fragment and an aldehyde c ...[more]