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Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation.

ABSTRACT: The marine macrolide bryostatin 7 is prepared in 20 steps (longest linear sequence) and 36 total steps with five C-C bonds formed using hydrogenative methods. This approach represents the most concise synthesis of any bryostatin reported, to date.

SUBMITTER: Lu Y

PROVIDER: S-EPMC3164899 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation.

Lu Yu Y Woo Sang Kook SK Krische Michael J MJ

Journal of the American Chemical Society 20110811 35

The marine macrolide bryostatin 7 is prepared in 20 steps (longest linear sequence) and 36 total steps with five C-C bonds formed using hydrogenative methods. This approach represents the most concise synthesis of any bryostatin reported, to date. ...[more]

PMID: 21780806

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