Ontology highlight
ABSTRACT:
SUBMITTER: Sehrawat S
PROVIDER: S-EPMC3031489 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Sehrawat Seema S Ernandez Thomas T Cullere Xavier X Takahashi Mikiko M Ono Yoshitaka Y Komarova Yulia Y Mayadas Tanya N TN
Blood 20101015 2
Adhesive forces at endothelial cell-cell borders maintain vascular integrity. cAMP enhances barrier properties and controls cellular processes through protein kinase A bound to A-kinase anchoring proteins (AKAPs). It also activates exchange protein directly activated by cAMP (Epac1), an exchange factor for Ras-related protein 1 (Rap1) GTPases that promotes cadherin- and integrin-mediated adhesion through effects on the actin cytoskeleton. We demonstrate that AKAP9 facilitates the microtubule pol ...[more]