Ontology highlight
ABSTRACT:
SUBMITTER: Goes FS
PROVIDER: S-EPMC3032172 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Goes F S FS Willour V L VL Zandi P P PP Belmonte P L PL MacKinnon D F DF Mondimore F M FM Schweizer B B DePaulo J R JR Gershon E S ES McMahon F J FJ Potash J B JB
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20100301 2
The Reelin gene (RELN) encodes a secretory glycoprotein critical for brain development and synaptic plasticity. Post-mortem studies have shown lower Reelin protein levels in the brains of patients with schizophrenia and bipolar disorder (BP) compared with controls. In a recent genome-wide association study of schizophrenia, the strongest association was found in a marker within RELN, although this association was seen only in women. In this study, we investigated whether genetic variation in REL ...[more]