Ontology highlight
ABSTRACT:
SUBMITTER: Lo Vasco VR
PROVIDER: S-EPMC3590364 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Lo Vasco Vincenza Rita VR Longo Lucia L Polonia Patrizia P
Journal of cell communication and signaling 20121117 1
The involvement of phosphoinositides (PI) signal transduction pathway and related molecules, such as the Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes, in the pathophysiology of mood disorders is corroborated by a number of recent evidences. Our previous works identified the deletion of PLCB1 gene, which codifies for the PI-PLC β1 enzyme, in 4 out 15 patients affected with schizophrenia, and no deletion both in major depression affected patients and in normal controls. By using inte ...[more]