Ontology highlight
ABSTRACT:
SUBMITTER: Miller SA
PROVIDER: S-EPMC3032266 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Miller Sara A SA Mohn Sarah E SE Weinmann Amy S AS
Molecular cell 20101101 4
The stable and heritable H3K27-methyl mark suppresses transcription of lineage-specific genes in progenitor cells. During developmental transitions, histone demethylases are required to dramatically alter epigenetic and gene expression states to create new cell-specific profiles. It is unclear why demethylase proteins that antagonize polycomb-mediated repression continue to be expressed in terminally differentiated cells where further changes in H3K27 methylation could be deleterious. In this st ...[more]