Ontology highlight
ABSTRACT:
SUBMITTER: Bolduc FV
PROVIDER: S-EPMC3038669 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Bolduc François V FV Bell Kimberly K Cox Hilary H Broadie Kendal S KS Tully Tim T
Nature neuroscience 20080907 10
We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition. ...[more]