Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila.
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ABSTRACT:
SUBMITTER: Fitzsimons HL
PROVIDER: S-EPMC3240647 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
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Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila.
Fitzsimons Helen L HL Scott Maxwell J MJ
PloS one 20111215 12
There is increasing evidence that regulation of local chromatin structure is a critical mechanism underlying the consolidation of long-term memory (LTM), however considerably less is understood about the specific mechanisms by which these epigenetic effects are mediated. Furthermore, the importance of histone acetylation in Drosophila memory has not been reported. The histone deacetylase (HDAC) Rpd3 is abundant in the adult fly brain, suggesting a post-mitotic function. Here, we investigated the ...[more]
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