Genome-wide association studies of atrial fibrillation: past, present, and future.
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ABSTRACT:
SUBMITTER: Sinner MF
PROVIDER: S-EPMC3039249 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Genome-wide association studies of atrial fibrillation: past, present, and future.
Sinner Moritz F MF Ellinor Patrick T PT Meitinger Thomas T Benjamin Emelia J EJ Kääb Stefan S
Cardiovascular research 20110118 4
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directi ...[more]
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