Ontology highlight
ABSTRACT:
SUBMITTER: Giordano D
PROVIDER: S-EPMC3040463 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Giordano Daniela D Li Chang C Suthar Mehul S MS Draves Kevin E KE Ma Daphne Y DY Gale Michael M Clark Edward A EA
Journal of leukocyte biology 20101222 3
Using NOS2 KO mice, we investigated the hypothesis that NO modulation of BM-DC contributes to the NO-mediated control of Th1 immune responses. BM-DCs from NOS2 KO mice, compared with WT BM-DCs, have enhanced survival and responsiveness to TLR agonists, develop more Ly6C(hi)PDCA1(+) DCs that resemble inflammatory DCs and produce high levels of inflammatory cytokines. Also, compared with WT-infected mice, NOS2 KO mice infected with WNV showed enhanced expansion of a similar inflammatory Ly6C(hi)PD ...[more]