Ontology highlight
ABSTRACT:
SUBMITTER: Cornelius SP
PROVIDER: S-EPMC3044393 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Cornelius Sean P SP Lee Joo Sang JS Motter Adilson E AE
Proceedings of the National Academy of Sciences of the United States of America 20110207 8
Gene-knockout experiments on single-cell organisms have established that expression of a substantial fraction of genes is not needed for optimal growth. This problem acquired a new dimension with the recent discovery that environmental and genetic perturbations of the bacterium Escherichia coli are followed by the temporary activation of a large number of latent metabolic pathways, which suggests the hypothesis that temporarily activated reactions impact growth and hence facilitate adaptation in ...[more]