Ontology highlight
ABSTRACT:
SUBMITTER: Staszewski O
PROVIDER: S-EPMC3044441 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Staszewski Ori O Baker Richard E RE Ucher Anna J AJ Martier Raygene R Stavnezer Janet J Guikema Jeroen E J JE
Molecular cell 20110101 2
After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen-binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading to antibody class switch recombination (CSR). We asked if, during B cell activation, AID also induces DNA breaks at genes other than IgH genes. Using a nonbiased genome-wide approach, we have identif ...[more]