Ontology highlight
ABSTRACT:
SUBMITTER: Morrow JK
PROVIDER: S-EPMC3807665 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Morrow John Kenneth JK Zhang Shuxing S
Current pharmaceutical design 20120101 9
Most biological processes involve multiple proteins interacting with each other. It has been recently discovered that certain residues in these protein-protein interactions, which are called hot spots, contribute more significantly to binding affinity than others. Hot spot residues have unique and diverse energetic properties that make them challenging yet important targets in the modulation of protein-protein complexes. Design of therapeutic agents that interact with hot spot residues has prove ...[more]