Ontology highlight
ABSTRACT:
SUBMITTER: Yan WL
PROVIDER: S-EPMC3051611 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Acta crystallographica. Section E, Structure reports online 20110129 Pt 2
In the title compound, C(21)H(26)N(2)O(2)S, the cyclo-hexane ring adopts a chair conformation. The angle at the methyl-ene bridge linking the pyrimidine and cyclo-hexane rings is 113.41 (13)°. This is in the range considered optimal for maximum activity of non-nucleoside reverse transcriptase inhibitors. In the crystal, mol-ecules are connected into centrosymmetric dimers via pairs of N-H⋯O hydrogen bonds. ...[more]