Ontology highlight
ABSTRACT:
SUBMITTER: Beutler LR
PROVIDER: S-EPMC3054029 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Beutler Lisa R LR Wanat Matthew J MJ Quintana Albert A Sanz Elisenda E Bamford Nigel S NS Zweifel Larry S LS Palmiter Richard D RD
Proceedings of the National Academy of Sciences of the United States of America 20110222 10
Signaling through N-methyl-D-aspartate-type glutamate receptors (NMDARs) is essential for the development of behavioral sensitization to psychostimulants such as amphetamine (AMPH). However, the cell type and brain region in which NMDAR signaling is required for AMPH sensitization remain unresolved. Here we use selective inactivation of Grin1, the gene encoding the essential NR1 subunit of NMDARs, in dopamine neurons or their medium spiny neuron (MSN) targets, to address this issue. We show that ...[more]