Ontology highlight
ABSTRACT:
SUBMITTER: Frank MJ
PROVIDER: S-EPMC3055524 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Frank Michael J MJ Fossella John A JA
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100714 1
Many of the individual differences in cognition, motivation, and learning-and the disruption of these processes in neurological conditions-are influenced by genetic factors. We provide an integrative synthesis across human and animal studies, focusing on a recent spate of evidence implicating a role for genes controlling dopaminergic function in frontostriatal circuitry, including COMT, DARPP-32, DAT1, DRD2, and DRD4. These genetic effects are interpreted within theoretical frameworks developed ...[more]