Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Y
PROVIDER: S-EPMC3056176 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Cheng Yu Y Meyers Joseph D JD Broome Ann-Marie AM Kenney Malcolm E ME Basilion James P JP Burda Clemens C
Journal of the American Chemical Society 20110204 8
Efficient drug delivery to tumors is of ever-increasing importance. Single-visit diagnosis and treatment sessions are the goal of future theranostics. In this work, a noncovalent PDT cancer drug-gold nanoparticle (Au NP) conjugate system performed a rapid drug release and deep penetration of the drug into tumors within hours. The drug delivery mechanism of the PDT drug through Au NPs into tumors by passive accumulation was investigated via fluorescence imaging, elemental analysis, and histologic ...[more]