Ontology highlight
ABSTRACT:
SUBMITTER: Vermillion K
PROVIDER: S-EPMC3057138 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Vermillion Karl K Holguin F Omar FO Berhow Mark A MA Richins Richard D RD Redhouse Thurman T O'Connell Mary A MA Posakony Jeff J Mahajan Sumit S SS Kelly Sean M SM Simon Julian A JA
Journal of natural products 20110131 2
A new withanolide, dinoxin B (12,21-dihydroxy-1-oxowitha-2,5,24-trienolide-27-O-β-D-glucopyranoside, 1), was isolated from a methanol extract of Datura inoxia leaves, using bioassay-guided fractionation. The structure was determined by spectroscopic techniques, including (1)H, (13)C, and 2D NMR experiments as well as by HRMS. Extracts and the purified compound were tested for their antiproliferative activities toward a panel of human normal and cancer cell lines. Dinoxin B (1) and its aglycone ( ...[more]