Ontology highlight
ABSTRACT:
SUBMITTER: Faas GC
PROVIDER: S-EPMC3057387 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Faas Guido C GC Raghavachari Sridhar S Lisman John E JE Mody Istvan I
Nature neuroscience 20110123 3
Many forms of signal transduction occur when Ca(2+) enters the cytoplasm of a cell. It has been generally thought that there is a fast buffer that rapidly reduces the free Ca(2+) level and that it is this buffered level of Ca(2+) that triggers downstream biochemical processes, notably the activation of calmodulin (CaM) and the resulting activation of CaM-dependent enzymes. Given the importance of these transduction processes, it is crucial to understand exactly how Ca(2+) activates CaM. We have ...[more]