Ontology highlight
ABSTRACT:
SUBMITTER: Welsby PJ
PROVIDER: S-EPMC6740846 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Welsby Philip J PJ Wang Hongge H Wolfe Joshua T JT Colbran Roger J RJ Johnson Michael L ML Barrett Paula Q PQ
The Journal of neuroscience : the official journal of the Society for Neuroscience 20031101 31
Low-voltage-activated (LVA) Ca2+ channels are widely distributed throughout the CNS and are important determinants of neuronal excitability, initiating dendritic and somatic Ca2+ spikes that trigger and shape the pattern of action potential firing. Here, we define a molecular mechanism underlying the dynamic regulation of alpha1H channels (Cav3.2), by Ca2+/CaM-dependent protein kinase II (CaMKII). We show that channel regulation is selective for the LVA alpha1H Ca2+ channel subtype, depends on d ...[more]