Ontology highlight
ABSTRACT:
SUBMITTER: Cheung YY
PROVIDER: S-EPMC3057427 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Cheung Yiu-Yin YY Zamorano Rocio R Blobaum Anna L AL Weaver C David CD Conn P Jeffrey PJ Lindsley Craig W CW Niswender Colleen M CM Hopkins Corey R CR
ACS combinatorial science 20110221 2
Using a functional high-throughput screening (HTS) and subsequent solution-phase parallel synthesis approach, we have discovered a novel series of positive allosteric modulators for mGlu₄, a G-protein coupled receptor. This series is comprised of a homopiperazine central core. The solution-phase parallel synthesis and SAR of analogs derived from this series will be presented. This series of positive allosteric modulators of mGlu₄ provide critical research tools to further probe the mGlu₄-mediate ...[more]