A role for IL-27p28 as an antagonist of gp130-mediated signaling.
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ABSTRACT:
SUBMITTER: Stumhofer JS
PROVIDER: S-EPMC3059498 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Stumhofer Jason S JS Tait Elia D ED Quinn William J WJ Hosken Nancy N Spudy Björn B Goenka Radhika R Fielding Ceri A CA O'Hara Aisling C AC Chen Yi Y Jones Michael L ML Saris Christiaan J M CJ Rose-John Stefan S Cua Daniel J DJ Jones Simon A SA Elloso Merle M MM Grötzinger Joachim J Cancro Michael P MP Levin Steven D SD Hunter Christopher A CA
Nature immunology 20101107 12
The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique functions. Here we show that IL-27p28, independently of EBI3, antagonized cytokine signaling through gp130 and IL-6-mediated production of IL-17 and IL-10. Similarly, the ability to ...[more]
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