Ontology highlight
ABSTRACT:
SUBMITTER: Baldock C
PROVIDER: S-EPMC3060269 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Baldock Clair C Oberhauser Andres F AF Ma Liang L Lammie Donna D Siegler Veronique V Mithieux Suzanne M SM Tu Yidong Y Chow John Yuen Ho JY Suleman Farhana F Malfois Marc M Rogers Sarah S Guo Liang L Irving Thomas C TC Wess Tim J TJ Weiss Anthony S AS
Proceedings of the National Academy of Sciences of the United States of America 20110228 11
Elastin enables the reversible deformation of elastic tissues and can withstand decades of repetitive forces. Tropoelastin is the soluble precursor to elastin, the main elastic protein found in mammals. Little is known of the shape and mechanism of assembly of tropoelastin as its unique composition and propensity to self-associate has hampered structural studies. In this study, we solve the nanostructure of full-length and corresponding overlapping fragments of tropoelastin using small angle X-r ...[more]