Ontology highlight
ABSTRACT:
SUBMITTER: Xing L
PROVIDER: S-EPMC4758957 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Xing Lei L Larsen Rylan S RS Bjorklund George Reed GR Li Xiaoyan X Wu Yaohong Y Philpot Benjamin D BD Snider William D WD Newbern Jason M JM
eLife 20160205
Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis. Here, we have determined the functions of ERK/MAPK signaling in developing neocortical excitatory neurons. Our data reveal a critical requirement for ERK/MAPK signaling in the morphological development and survival of large Ctip2(+) neurons in layer 5. Loss of Map2k1/2 (Mek1/2) led to deficits in corticospinal ...[more]