Ontology highlight
ABSTRACT:
SUBMITTER: Aneiros E
PROVIDER: S-EPMC3061026 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Aneiros Eduardo E Cao Lishuang L Papakosta Marianthi M Stevens Edward B EB Phillips Stephen S Grimm Christian C
The EMBO journal 20110201 6
The capsaicin receptor TRPV1, a member of the transient receptor potential family of non-selective cation channels is a polymodal nociceptor. Noxious thermal stimuli, protons, and the alkaloid irritant capsaicin open the channel. The mechanisms of heat and capsaicin activation have been linked to voltage-dependent gating in TRPV1. However, until now it was unclear whether proton activation or potentiation or both are linked to a similar voltage-dependent mechanism and which molecular determinant ...[more]