Ontology highlight
ABSTRACT:
SUBMITTER: Lee BH
PROVIDER: S-EPMC4516785 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
The Journal of general physiology 20150713 2
The TRPV1 cation channel is a polymodal nociceptor that is activated by heat and ligands such as capsaicin and is highly sensitive to changes in extracellular pH. In the body core, where temperature is usually stable and capsaicin is normally absent, H(+) released in response to ischemia, tissue injury, or inflammation is the best-known endogenous TRPV1 agonist, activating the channel to mediate pain and vasodilation. Paradoxically, removal of H(+) elicits a transient increase in TRPV1 current t ...[more]