Ontology highlight
ABSTRACT:
SUBMITTER: Schepers AG
PROVIDER: S-EPMC3061032 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Schepers Arnout G AG Vries Robert R van den Born Maaike M van de Wetering Marc M Clevers Hans H
The EMBO journal 20110204 6
Somatic cells have been proposed to be limited in the number of cell divisions they can undergo. This is thought to be a mechanism by which stem cells retain their integrity preventing disease. However, we have recently discovered intestinal crypt stem cells that persist for the lifetime of a mouse, yet divide every day. We now demonstrate biochemically that primary isolated Lgr5+ve stem cells contain significant telomerase activity. Telomerase activity rapidly decreases in the undifferentiated ...[more]