Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.
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ABSTRACT:
SUBMITTER: Wang GY
PROVIDER: S-EPMC3061401 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice.
Wang Grace Ying GY Wang Joy J Mancianti Maria-Laura ML Epstein Ervin H EH
Cancer cell 20110106 1
Basal cell carcinomas (BCCs) are hedgehog-driven tumors that resemble follicular and interfollicular epidermal basal keratinocytes and hence long have been thought to arise from these cells. However, the actual cell of origin is unknown. Using cell fate tracking of X-ray induced BCCs in Ptch1(+/-) mice, we found their essentially exclusive origin to be keratin 15-expressing stem cells of the follicular bulge. However, conditional loss of p53 not only enhanced BCC carcinogenesis from the bulge bu ...[more]
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