Ontology highlight
ABSTRACT:
SUBMITTER: Peterson SC
PROVIDER: S-EPMC4387376 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Peterson Shelby C SC Eberl Markus M Vagnozzi Alicia N AN Belkadi Abdelmadjid A Veniaminova Natalia A NA Verhaegen Monique E ME Bichakjian Christopher K CK Ward Nicole L NL Dlugosz Andrzej A AA Wong Sunny Y SY
Cell stem cell 20150401 4
Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for Hedgehog in BCC is well established, the identity of disease-initiating cells and the compartments in which they reside remain controversial. By using several inducible Cre drivers to delete Ptch1 in different cell compartments in mice, we show here that multiple hair follicle stem cell populations readily develop BCC-like tumors. In cont ...[more]