Ontology highlight
ABSTRACT:
SUBMITTER: Choi WS
PROVIDER: S-EPMC3061491 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Choi Won-Seok WS Abel Glen G Klintworth Heather H Flavell Richard A RA Xia Zhengui Z
Journal of neuropathology and experimental neurology 20100501 5
Mechanistic studies underlying dopaminergic neuron death may identify new drug targets for the treatment of Parkinson disease. Epidemiological studies have linked pesticide exposure to increased risk for sporadic Parkinson disease. Here, we investigated the role of c-Jun-N-terminal kinase 3 (JNK3), a neural-specific JNK isoform, in dopaminergic neuron death induced by the pesticides rotenone and paraquat. The role of JNK3 was evaluated using RNA silencing and gene deletion to block JNK3 signalin ...[more]