C-Jun mediates axotomy-induced dopamine neuron death in vivo.
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ABSTRACT:
SUBMITTER: Crocker SJ
PROVIDER: S-EPMC60880 | biostudies-literature | 2001 Nov
REPOSITORIES: biostudies-literature
Publications
c-Jun mediates axotomy-induced dopamine neuron death in vivo.
Crocker S J SJ Lamba W R WR Smith P D PD Callaghan S M SM Slack R S RS Anisman H H Park D S DS
Proceedings of the National Academy of Sciences of the United States of America 20011030 23
Expression of the transcription factor c-Jun is induced in neurons of the central nervous system (CNS) in response to injury. Mechanical transection of the nigrostriatal pathway at the medial forebrain bundle (MFB) results in the delayed retrograde degeneration of the dopamine neurons in the substantia nigra pars compacta (SNc) and induces protracted expression and phosphorylation of c-Jun. However, the role of c-Jun after axotomy of CNS neurons is unclear. Here, we show that adenovirus-mediated ...[more]
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