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A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis.

ABSTRACT: Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.

SUBMITTER: Wang D

PROVIDER: S-EPMC3061842 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis.

Wang Danher D Suhrbier Andreas A Penn-Nicholson Adam A Woraratanadharm Jan J Gardner Joy J Luo Min M Le Thuy T TT Anraku Itaru I Sakalian Michael M Einfeld David D Dong John Y JY

Vaccine 20110212 15

Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced ...[more]

PMID: 21320541

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