A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line.

ABSTRACT: The methylation of lysine 4 of Histone H3 (H3K4me) is an important component of epigenetic regulation. H3K4 methylation is a consequence of transcriptional activity, but also has been shown to contribute to "epigenetic memory"; i.e., it can provide a heritable landmark of previous transcriptional activity that may help promote or maintain such activity in subsequent cell descendants or lineages. A number of multi-protein complexes that control the addition of H3K4me have been described in several organisms. These Set1/MLL or COMPASS complexes often share a common subset of conserved proteins, with other components potentially contributing to tissue-specific or developmental regulation of the methyltransferase activity. Here we show that the normal maintenance of H3K4 di- and tri-methylatio

SUBMITTER: Li T 

PROVIDER: S-EPMC3063756 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature