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Importin ?7 is essential for zygotic genome activation and early mouse development.

ABSTRACT: Importin ? is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin ?7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin ?7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin ?7 is a new member of the small group of maternal effect genes.

SUBMITTER: Rother F

PROVIDER: S-EPMC3066239 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Importin α7 is essential for zygotic genome activation and early mouse development.

Rother Franziska F Shmidt Tatiana T Popova Elena E Krivokharchenko Alexander A Hügel Stefanie S Vilianovich Larissa L Ridders Michael M Tenner Katja K Alenina Natalia N Köhler Matthias M Hartmann Enno E Bader Michael M

PloS one 20110329 3

Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely d ...[more]

PMID: 21479251

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