IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
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ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC4602366 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Yu Jingyou J Li Minghua M Wilkins Jordan J Ding Shilei S Swartz Talia H TH Esposito Anthony M AM Zheng Yi-Min YM Freed Eric O EO Liang Chen C Chen Benjamin K BK Liu Shan-Lu SL
Cell reports 20150917 1
The interferon-induced transmembrane (IFITM) proteins have been recently shown to restrict HIV-1 and other viruses. Here, we provide evidence that IFITM proteins, particularly IFITM2 and IFITM3, specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection. IFITM proteins interact with HIV-1 Env in viral producer cells, leading to impaired Env processing and virion incorporation. Notably, the level of IFITM incorporation into HIV-1 virions does not strictly co ...[more]
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