IFITM proteins inhibit HIV-1 protein synthesis.
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ABSTRACT:
SUBMITTER: Lee WJ
PROVIDER: S-EPMC6162285 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
IFITM proteins inhibit HIV-1 protein synthesis.
Lee Wing-Yiu Jason WJ Fu Rebecca Menhua RM Liang Chen C Sloan Richard D RD
Scientific reports 20180928 1
Interferon induced transmembrane proteins (IFITMs) inhibit the cellular entry of a broad range of viruses, but it has been suspected that for HIV-1 IFITMs may also inhibit a post-integration replicative step. We show that IFITM expression reduces HIV-1 viral protein synthesis by preferentially excluding viral mRNA transcripts from translation and thereby restricts viral production. Codon-optimization of proviral DNA rescues viral translation, implying that IFITM-mediated restriction requires rec ...[more]
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