Ontology highlight
ABSTRACT:
SUBMITTER: Guan W
PROVIDER: S-EPMC3067811 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Guan Wuxiang W Cheng Fang F Huang Qinfeng Q Kleiboeker Steve S Qiu Jianming J
Journal of virology 20101215 5
Alternative splicing of the precursor mRNA (pre-mRNA) of human parvovirus B19 (B19V) plays a key role in posttranscriptional regulation of B19V gene expression. We report that the central exon of the B19V pre-mRNA is defined by three GAA motif-containing exonic splicing enhancers and a G/GU-rich intronic splicing enhancer that lies adjacent to the second donor site. Moreover, targeting of morpholino antisense oligonucleotides to the two splicing enhancers surrounding the second donor site led to ...[more]