Ontology highlight
ABSTRACT:
SUBMITTER: Huang Z
PROVIDER: S-EPMC3068302 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Huang Zhuo Z Lujan Rafael R Kadurin Ivan I Uebele Victor N VN Renger John J JJ Dolphin Annette C AC Shah Mala M MM
Nature neuroscience 20110227 4
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are subthreshold, voltage-gated ion channels that are highly expressed in hippocampal and cortical pyramidal cell dendrites, where they are important for regulating synaptic potential integration and plasticity. We found that HCN1 subunits are also localized to the active zone of mature asymmetric synaptic terminals targeting mouse entorhinal cortical layer III pyramidal neurons. HCN channels inhibited glutamate synaptic rele ...[more]