Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez D
PROVIDER: S-EPMC3578406 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Hernandez Daniela D Torres Ciara A CA Setlik Wanda W Cebrián Carolina C Mosharov Eugene V EV Tang Guomei G Cheng Hsiao-Chun HC Kholodilov Nikolai N Yarygina Olga O Burke Robert E RE Gershon Michael M Sulzer David D
Neuron 20120401 2
mTOR is a regulator of cell growth and survival, protein synthesis-dependent synaptic plasticity, and autophagic degradation of cellular components. When triggered by mTOR inactivation, macroautophagy degrades long-lived proteins and organelles via sequestration into autophagic vacuoles. mTOR further regulates synaptic plasticity, and neurodegeneration occurs when macroautophagy is deficient. It is nevertheless unknown whether macroautophagy modulates presynaptic function. We find that the mTOR ...[more]