Ontology highlight
ABSTRACT:
SUBMITTER: Padilla S
PROVIDER: S-EPMC3070445 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Padilla S S Tran U C UC Jiménez-Hidalgo M M López-Martín J M JM Martín-Montalvo A A Clarke C F CF Navas P P Santos-Ocaña C C
Cellular and molecular life sciences : CMLS 20090101 1
Coenzyme Q is a lipid molecule required for respiration and antioxidant protection. Q biosynthesis in Saccharomyces cerevisiae requires nine proteins (Coq1p-Coq9p). We demonstrate in this study that Q levels are modulated during growth by its conversion from demethoxy-Q (DMQ), a late intermediate. Similar conversion was produced when cells were subjected to oxidative stress conditions. Changes in Q(6)/DMQ(6) ratio were accompanied by changes in COQ7 gene mRNA levels encoding the protein responsi ...[more]