Ontology highlight
ABSTRACT:
SUBMITTER: Hajj Chehade M
PROVIDER: S-EPMC3707705 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Hajj Chehade Mahmoud M Loiseau Laurent L Lombard Murielle M Pecqueur Ludovic L Ismail Alexandre A Smadja Myriam M Golinelli-Pimpaneau Béatrice B Mellot-Draznieks Caroline C Hamelin Olivier O Aussel Laurent L Kieffer-Jaquinod Sylvie S Labessan Natty N Barras Frédéric F Fontecave Marc M Pierrel Fabien F
The Journal of biological chemistry 20130524 27
Coenzyme Q (ubiquinone or Q) is a redox-active lipid found in organisms ranging from bacteria to mammals in which it plays a crucial role in energy-generating processes. Q biosynthesis is a complex pathway that involves multiple proteins. In this work, we show that the uncharacterized conserved visC gene is involved in Q biosynthesis in Escherichia coli, and we have renamed it ubiI. Based on genetic and biochemical experiments, we establish that the UbiI protein functions in the C5-hydroxylation ...[more]