Ontology highlight
ABSTRACT:
SUBMITTER: Johnson DS
PROVIDER: S-EPMC6080951 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Johnson Daniel S DS Bleck Marina M Simon Sanford M SM
eLife 20180704
The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis. Some viruses appropriate ESCRT-IIIs for their release. By imaging single assembling viral-like particles of HIV-1, we observed that ESCRT-IIIs and the ATPase VPS4 arrive after most of the virion membrane is bent, linger for tens of seconds, and depart ~20 s before scission. These observations sugg ...[more]