Ontology highlight
ABSTRACT:
SUBMITTER: Rodelsperger C
PROVIDER: S-EPMC3074119 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Rödelsperger Christian C Guo Gao G Kolanczyk Mateusz M Pletschacher Angelika A Köhler Sebastian S Bauer Sebastian S Schulz Marcel H MH Robinson Peter N PN
Nucleic acids research 20101124 7
Multicellular organismal development is controlled by a complex network of transcription factors, promoters and enhancers. Although reliable computational and experimental methods exist for enhancer detection, prediction of their target genes remains a major challenge. On the basis of available literature and ChIP-seq and ChIP-chip data for enhanceosome factor p300 and the transcriptional regulator Gli3, we found that genomic proximity and conserved synteny predict target genes with a relatively ...[more]