Ontology highlight
ABSTRACT:
SUBMITTER: Nallagatla SR
PROVIDER: S-EPMC3075410 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Nallagatla Subba Rao SR Toroney Rebecca R Bevilacqua Philip C PC
Current opinion in structural biology 20101208 1
Molecular recognition of RNA structure is key to innate immunity. The protein kinase PKR differentiates self from non-self by recognition of molecular patterns in RNA. Certain biological RNAs induce autophosphorylation of PKR, activating it to phosphorylate eukaryotic initiation factor 2α (eIF2α), which leads to inhibition of translation. Additional biological RNAs inhibit PKR, while still others have no effect. The aim of this article is to develop a cohesive framework for understanding and pre ...[more]