Ontology highlight
ABSTRACT:
SUBMITTER: Mazzone A
PROVIDER: S-EPMC3075685 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Mazzone Amelia A Bernard Cheryl E CE Strege Peter R PR Beyder Arthur A Galietta Luis J V LJ Pasricha Pankaj J PJ Rae James L JL Parkman Henry P HP Linden David R DR Szurszewski Joseph H JH Ördög Tamas T Gibbons Simon J SJ Farrugia Gianrico G
The Journal of biological chemistry 20110224 15
Diabetes affects many organs including the stomach. Altered number and function of interstitial cells of Cajal (ICC), the gastrointestinal pacemaker cells, underlie a number of gastrointestinal motility disorders, including diabetic gastroparesis. In the muscle layers, ICC selectively express Ano1, thought to underlie classical Ca(2+)-activated Cl(-) currents. Mice homozygous for Ano1 knock-out exhibit abnormal ICC function and motility. Several transcripts for Ano1 are generated by alternative ...[more]