Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3076053 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Wang Yan Y Ozawa Atsushi A Zaman Shadia S Prasad Nijaguna B NB Chandrasekharappa Settara C SC Agarwal Sunita K SK Marx Stephen J SJ
Cancer research 20101202 2
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder associated mainly with tumors of multiple endocrine organs. Mutations in the MEN1 gene that encodes for the menin protein are the predominant cause for hereditary MEN1 syndrome. Though menin is a tumor suppressor, its molecular mechanism of action has not been defined. Here, we report that menin interacts with AKT1 in vitro and in vivo. Menin downregulates the level of active AKT and its kinase activity. Through interac ...[more]