Ontology highlight
ABSTRACT:
SUBMITTER: Wu YH
PROVIDER: S-EPMC7198492 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Wu Yung-Hsuan YH Chou Ting-Fang TF Young Leslie L Hsieh Fu-Yi FY Pan Hsuan-Yin HY Mo Shu-Ting ST Brown Shani Bialik SB Chen Ruey-Hwa RH Kimchi Adi A Lai Ming-Zong MZ
Cell death & disease 20200504 5
Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages and dendritic cells susceptible to necroptotic death. We also observed an inhibitory role for DAPK1 in necroptosis in HT-29 cells, since knockdown or knockout of DAPK1 in such cells increased their sensitivity to necroptosis. Increased necroptosis wa ...[more]