Ontology highlight
ABSTRACT:
SUBMITTER: Feng L
PROVIDER: S-EPMC3079386 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Feng Liang L Campbell Ernest B EB Hsiung Yichun Y MacKinnon Roderick R
Science (New York, N.Y.) 20100930 6004
CLC proteins transport chloride (Cl(-)) ions across cell membranes to control the electrical potential of muscle cells, transfer electrolytes across epithelia, and control the pH and electrolyte composition of intracellular organelles. Some members of this protein family are Cl(-) ion channels, whereas others are secondary active transporters that exchange Cl(-) ions and protons (H(+)) with a 2:1 stoichiometry. We have determined the structure of a eukaryotic CLC transporter at 3.5 angstrom reso ...[more]