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Enantioselective Decarboxylative Arylation of ?-Amino Acids via the Merger of Photoredox and Nickel Catalysis.

ABSTRACT: An asymmetric decarboxylative Csp(3)-Csp(2) cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant ?-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents.

SUBMITTER: Zuo Z

PROVIDER: S-EPMC4862596 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis.

Zuo Zhiwei Z Cong Huan H Li Wei W Choi Junwon J Fu Gregory C GC MacMillan David W C DW

Journal of the American Chemical Society 20160205 6

An asymmetric decarboxylative Csp(3)-Csp(2) cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant α-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically active agents. ...[more]

PMID: 26849354

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